Dr Gupta graduated as a national talent scholar from the All India Institute of Medical Sciences, New Delhi, India. After spending 6 years in the UK at Queen Elizabeth Hospital in Birmingham and at the St James University Hospital in Leeds, he returned to India in 1998 and joined the Sir Ganga Ram Hospital in New Delhi as a Consultant in Liver Transplantation and Gastrointestinal Surgery. As cadaveric donations were rare, Dr Gupta introduced right lobe adult-to-adult liver transplantation to the hospital. His group at CLBS has been credited for
performing liver transplants in patients with unusual and difficult conditions, such as portal biliopathy, co-existing HIV infections, and donors/recipients with situs inversus. In 2009, his team introduced the posterior sector graft for increased donor safety in India, and was instrumental in pioneering hepatic transplantation in babies under 6 months of age. His team has also developed guidelines on liver transplantation and the treatment of liver diseases in India. His group has trained many teams and surgeons from around the world in liver transplantation.
In 2008, Dr Gupta was appointed Associate Professor of Surgery at the University of Queensland in Queensland, Australia, and in 2010, he became Professor of Liver Transplantation at the Institute of Postgraduate Education and Medical Research in Kolkata, India. In 2012, he was honoured by the Rotary Association of India for excellence in clinical medicine, and in the same year, he was the recipient of the Vishist Chikitshak Rattan (distinguished clinician) award. Dr Gupta has published over 30 papers in surgery and transplantation, and his research focuses on post operative management of liver transplant recipients.